Do proteolytic cascades exist in plants?

Design of Inhibitors for Proteolytic Cascades

Proteases are involved in the regulation of a wide variety of essential physiological processes, often by participating in a highly orchestrated sequence of events termed a ‘proteolytic cascade’. Four major proteolytic cascades with disease relevance are candidates for therapeutic intervention, namely caspasemediated apoptosis, blood coagulation, the matrix metalloproteinase cascade and the com...

Do Black Holes Exist?

Proof that black holes exist will likely require confirmation of the existence of event horizons. The common assumption that the mere existence of large compact masses proves the case for black holes is an unwarranted extrapolation of General Relativity into a strong-field regime where it has not been adequately tested. Neither the large compact masses of galactic nuclei nor the massive compact...

Do discrete emotions exist?

Do Pioneer Cells Exist?

Most mathematical models of collective cell spreading make the standard assumption that the cell diffusivity and cell proliferation rate are constants that do not vary across the cell population. Here we present a combined experimental and mathematical modeling study which aims to investigate how differences in the cell diffusivity and cell proliferation rate amongst a population of cells can i...

Do acupuncture points exist?

We used synchrotron x-ray fluorescence analysis to probe the distribution of four chemical elements in and around acupuncture points, two located in the forearm and two in the lower leg. Three of the four acupuncture points showed significantly elevated concentrations of elements Ca, Fe, Cu and Zn in relation to levels in the surrounding tissue, with similar elevation ratios for Cu and Fe. The ...